Development of Wear Resistant Metal Material for Screw & Cylinder of Twin Screw Extruder

Continuous Granulation with a Twin-Screw Extruder

Wet granulation in a twin-screw extruder: implications of screw design.

Wet granulation in twin-screw extrusion machinery is an attractive technology for the continuous processing of pharmaceuticals. The performance of this machinery is integrally tied to its screw design yet little fundamental knowledge exists in this emerging field for granulation to intelligently create, troubleshoot, and scale-up such processes. This study endeavored to systematically examine t...

Sequential calculation of torque in procedure of twin screw extrusion

The drug making resreach has accentuated on extrusion technology for a long time. The advance of drug bioavailibility, bead manufacturing and granulation is assured by extrusion procedures. There are also diverse effects in resereches with respect to the use of process understanging as a tool in quality management. Many initiatives of FDA such as PAT and QBD are getting accepted. In this survey...

Preparation of solid dispersion for ethenzamide-carbopol and theophylline-carbopol systems using a twin screw extruder.

In the present study, we prepared solid dispersions of water-insoluble and soluble drugs (ethenzamide (ETZ) and theophylline (THEO)) by the twin screw extruder method, which made it possible to control both kneading and heating at the same time under the fusion point of each drug, using three types of the controlled-release high-molecular-weight substance Carbopol (CAR) as the carrier. The soli...

Design of Synthetic Optimizing Neuro Fuzzy Temperature Controller for Twin Screw Profile Plastic Extruder Using Labview

Problem statement: The temperature control in plastic extrusion machine is an important factor to produce high quality plastic products. The first order temperature control system in plastic extrusion comprises of coupling effects, long delay time and large time constants. Controlling temperature is very difficult as the process is multistage process and the system coupled with each other. In o...